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貪食を介さないプレセプシン産生機序に関する検討
https://doi.org/10.20608/00000963
https://doi.org/10.20608/0000096318b18675-2daa-4021-aa11-7fad9276646a
名前 / ファイル | ライセンス | アクション |
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Bulletin11_12.pdf (2.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-03-31 | |||||
タイトル | ||||||
タイトル | 貪食を介さないプレセプシン産生機序に関する検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Mechanism of presepsin production through a phagocytosis -independent pathway | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 敗血症 | |||||
キーワード | ||||||
主題 | プレセプシン | |||||
キーワード | ||||||
主題 | 貪食 | |||||
キーワード | ||||||
主題 | CD14 | |||||
キーワード | ||||||
主題 | sepsis | |||||
キーワード | ||||||
主題 | presepsin | |||||
キーワード | ||||||
主題 | phagocytosis | |||||
キーワード | ||||||
主題 | CD14 | |||||
資源タイプ | ||||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.20608/00000963 | |||||
ID登録タイプ | JaLC | |||||
著者 |
溝越, 祐志
× 溝越, 祐志× 澤村, 暢× 鈴木, 高史× MIZOKOSHI, Yuji× SAWAMURA, Toru× SUZUKI, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | プレセプシンは敗血症のバイオマーカーであり、単球膜上のCD14が貪食時に分解され産生される。しかし、プレセプシンは健常人にも存在しており、その産生機序についての報告はない。本研究では健常人からのプレセプシン産生機序を探索するため、単球系に分化させたHL-60および、CD14を発現させた293T細胞における病原体関連分子パターン(PAMPs)刺激によるプレセプシン産生を検討した。HL-60、293T細胞ともに、Escherichia coli (E. coli) 刺激がない状態においてもプレセプシン産生が認められた。しかしE. coli刺激により産生が増強されたのはHL-60のみであった。これらの結果から健常人の体内においてもE. coliなどのPAMPs刺激を必要としないプレセプシン産生経路が存在し、敗血症時に免疫細胞内で起こる経路とは異なることが示唆された。 | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Presepsin, produced by CD14 degradation in monocytes, is one of the biomarker proteins for sepsis. Moreover, healthy people also have presepsin ; however, no studies have elucidated the mechanism of presepsin production in healthy bodies. To clarify the mechanism of presepsin production in healthy individuals, we studied whether HL-60 induced to differentiate in monocyte and human embryonic kidney (HEK) 293 T cells expressing CD14 can produce presepsin by the stimulation of pathogen - associated molecular patterns (PAMPs). We observed presepsin production in both HL-60 and HEK 293T cells, not only in the presence of E. coli but also in its absence. We also observed that E. coli stimulation enhanced the presepsin production in HL-60, but did not enhance it in HEK293T cells. These results suggest that there is a presepsin production pathway requiring no stimulation of PAMPs such as E. coli in a healthy person, and that this pathway is different from presepsin production in immune cells during sepsis. | |||||
書誌情報 |
神戸常盤大学紀要 en : Bulletin of Kobe Tokiwa University 号 11, p. 97-106, 発行日 2018-03-31 |
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出版者 | ||||||
出版者 | 神戸常盤大学・神戸常盤大学短期大学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18845487 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |