{"created":"2023-06-20T13:10:19.394904+00:00","id":1142,"links":{},"metadata":{"_buckets":{"deposit":"0d05345d-1ef5-46f7-9a2d-1ebc49e46cac"},"_deposit":{"created_by":3,"id":"1142","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1142"},"status":"published"},"_oai":{"id":"oai:kobe-tokiwa.repo.nii.ac.jp:00001142","sets":["6:77"]},"author_link":["7193","7192","7191","7194","7091","5920","7092","2033"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"神戸常盤大学紀要"},{"bibliographic_title":"Bulletin of Kobe Tokiwa University","bibliographic_titleLang":"en"}]}]},"item_10002_description_25":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_description":"Monocytes/macrophages play central roles in iron recycling and iron homeostasis. Tissue-resident macrophages derive not only from bone marrow monocytes but also from fetal precursor cells. Development of spleen red pulp macrophages (RPMs), the key players of iron recycling, are induced by heme. Monocytes in peripheral blood consist of three subsets: classical, intermediate, and non-classical. Classical monocytes regulate inflammation and intravascular iron homeostasis. Non-classical monocytes maintain vascular homeostasis as patrolling monocytes. Monocytes/macrophages and iron participate in neurodegenerative disorders such as Alzheimer's Disease and severe infectious disorders such as COVID-19, and are intensively studied as therapeutic targets. "}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"単球・マクロファージ(MΦ)は、鉄リサイクルに重要な役割を果たしている。組織MΦには単球由来のものと胎生期の前駆細胞由来のものが存在する。鉄リサイクルの中心である赤脾髄MΦ(RPM)の単球からの分化は、ヘムによって促進される。末梢血単球にはclassical, intermediate, nonclassicalのサブセットが存在し、機能している。classical monocytesは血管内の鉄ホメオスタシス制御と炎症のエフェクターとして機能し、non-classical monocytesは patrolling monocytes として血管のホメオスタシス制御に機能している。単球・MΦによる鉄リサイクル、鉄ホメオスタシス制御は、アルツハイマー型認知症など中枢神経変性疾患にも、新型コロナウイルス感染(COVID-19)などの感染症の重症化にも関与し、これらを治療ターゲットとした臨床研究が進行している。"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.20608/00001132","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神戸常盤大学・神戸常盤大学短期大学部"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18845487","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井本, しおん"},{"creatorName":"イモト, シオン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西郷, 勝康"},{"creatorName":"サイゴウ, カツヤス","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"大渕, 絢子"},{"creatorName":"オオブチ, アヤコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"河野, 麻理"},{"creatorName":"コウノ, マリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IMOTO, Shion","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAIGO, Katsuyasu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHBUCHI, Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KONO, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-29"}],"displaytype":"detail","filename":"Bulletin14_04.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bulletin14_04.pdf","url":"https://kobe-tokiwa.repo.nii.ac.jp/record/1142/files/Bulletin14_04.pdf"},"version_id":"938d6656-0739-4aff-8f67-93522df1bea6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"単球サブセット"},{"subitem_subject":"組織マクロファージ"},{"subitem_subject":"赤脾髄マクロファージ"},{"subitem_subject":"ヘム"},{"subitem_subject":"フェロトーシス"},{"subitem_subject":"monocyte subsets"},{"subitem_subject":"tissue-resident macrophages"},{"subitem_subject":"red pulp macrophages"},{"subitem_subject":"heme"},{"subitem_subject":"ferroptosis"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"鉄リサイクルと鉄ホメオスタシスにおける単球とマクロファージの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鉄リサイクルと鉄ホメオスタシスにおける単球とマクロファージの役割"},{"subitem_title":"Roles of monocytes and macrophages on iron recycle and homeostasis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"3","path":["77"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-31"},"publish_date":"2021-03-31","publish_status":"0","recid":"1142","relation_version_is_last":true,"title":["鉄リサイクルと鉄ホメオスタシスにおける単球とマクロファージの役割"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T13:15:50.327924+00:00"}