@article{oai:kobe-tokiwa.repo.nii.ac.jp:00000452,
 author = {井本, しおん and 大野, 良治 and 青山, 信和 and 藤井, 正彦 and 後藤, 正徳 and 杉本, 健 and 西郷, 勝康 and IMOTO, Shion and OHNO, Yoshiharu and AOYAMA, Nobukazu and FUJII, Masahiko and GOTO, Masanori and SUGIMOTO, Takeshi and SAIGO, Katsuyasu},
 issue = {3},
 journal = {神戸常盤大学紀要, Bulletin of Kobe Tokiwa University},
 month = {Apr},
 note = {【背景】血液疾患では長期輸血等で鉄過剰となる。肝鉄量は鉄過剰の重要な指標であり、欧米では MRI によ る非侵襲的定量法が普及しつつあるが、日本では殆ど行われていない。【方法】Gandon らの論文に基づき、腹部 MRI をグラディエントエコー法(GRE)で撮影、肝臓(L)と脊筋(M)の信号強度比(L / M)を測定、論文中の L/C -肝鉄量相関図から肝鉄量推定値(LIC-MRI)を求め、 フェリチンなど血清学的マーカーと比較。【対象】正常者3名、血液疾患3名(輸血後鉄過剰症、慢性溶血性貧血、二次性骨髄線維症)。【結果】正常者3名の血清学的マーカーと LIC-MRI は正常範囲内だった。輸血後鉄過剰症と慢性溶血性貧血患 者では血清フェリチンと LIC-MRI は正常の約10倍だった。【結論】LIC-MRI はフェリチンと高い相関を示した。さらに症例数を増やして検討する必要がある。, Background: Iron overload is a major problem for patients with hematological diseases. Liver iron concentration (LIC) is an important marker of iron overload. LIC has been measured by MRI (Magnetic Resonance Imaging) instead of invasive hepatic biopsy in European countries, but not yet in Japan. Methods: LIC was measured by MRI according to Gandon's method (Lancet 2004;363:357-362) using gradient echo sequence (GRE). Signal intensity ratio of the liver and muscle (L/M) was measured. LIC was estimated from the linear correlation curve of L/M and LIC shown in Gandon's paper. LIC estimated from MRI (LIC-MRI) was compared with serological markers such as serum ferritin level. Patients:Three patients with hematological diseases (post-transfusion iron overload, chronic hemolytic anemia, secondary myelofibrosis) and three healthy persons as normal controls. Results: LIC-MRI and serological markers were normal among the three normal controls. Two patients showed ten times higher LIC-MRI and ferritin levels than normal ranges. Conclusion: LIC-MRI showed an excellent correlation with serum ferritin level. Because of low examination numbers for the present cases, further study is necessary., 1, KJ00008885199, 原著, Original Articale},
 pages = {1--10},
 title = {血液疾患患者の鉄過剰症に対する評価方法の検討:MRI による非侵襲的肝鉄量定量測定},
 year = {2011},
 yomi = {イモト, シオン and オオノ, ヨシハル and アオヤマ, ノブカズ and フジイ, マサヒコ and ゴトウ, マサノリ and スギモト, タケシ and サイゴウ, カツヤ}
}