{"created":"2023-06-20T13:09:49.096039+00:00","id":452,"links":{},"metadata":{"_buckets":{"deposit":"32c1ca7c-e20f-479c-9b1b-3662565cd428"},"_deposit":{"created_by":3,"id":"452","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"452"},"status":"published"},"_oai":{"id":"oai:kobe-tokiwa.repo.nii.ac.jp:00000452","sets":["6:15"]},"author_link":["5158","5165","5154","5159","5160","5163","5162","5167","5164","5156","5161","5155","5166","5157"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"神戸常盤大学紀要"},{"bibliographic_title":"Bulletin of Kobe Tokiwa University","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"【背景】血液疾患では長期輸血等で鉄過剰となる。肝鉄量は鉄過剰の重要な指標であり、欧米では MRI によ る非侵襲的定量法が普及しつつあるが、日本では殆ど行われていない。【方法】Gandon らの論文に基づき、腹部 MRI をグラディエントエコー法(GRE)で撮影、肝臓(L)と脊筋(M)の信号強度比(L / M)を測定、論文中の L/C -肝鉄量相関図から肝鉄量推定値(LIC-MRI)を求め、 フェリチンなど血清学的マーカーと比較。【対象】正常者3名、血液疾患3名(輸血後鉄過剰症、慢性溶血性貧血、二次性骨髄線維症)。【結果】正常者3名の血清学的マーカーと LIC-MRI は正常範囲内だった。輸血後鉄過剰症と慢性溶血性貧血患 者では血清フェリチンと LIC-MRI は正常の約10倍だった。【結論】LIC-MRI はフェリチンと高い相関を示した。さらに症例数を増やして検討する必要がある。","subitem_description_type":"Other"}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Background: Iron overload is a major problem for patients with hematological diseases. Liver iron concentration (LIC) is an important marker of iron overload. LIC has been measured by MRI (Magnetic Resonance Imaging) instead of invasive hepatic biopsy in European countries, but not yet in Japan. Methods: LIC was measured by MRI according to Gandon's method (Lancet 2004;363:357-362) using gradient echo sequence (GRE). Signal intensity ratio of the liver and muscle (L/M) was measured. LIC was estimated from the linear correlation curve of L/M and LIC shown in Gandon's paper. LIC estimated from MRI (LIC-MRI) was compared with serological markers such as serum ferritin level. Patients:Three patients with hematological diseases (post-transfusion iron overload, chronic hemolytic anemia, secondary myelofibrosis) and three healthy persons as normal controls. Results: LIC-MRI and serological markers were normal among the three normal controls. Two patients showed ten times higher LIC-MRI and ferritin levels than normal ranges. Conclusion: LIC-MRI showed an excellent correlation with serum ferritin level. Because of low examination numbers for the present cases, further study is necessary.","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"1","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00008885199","subitem_description_type":"Other"}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Articale","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://bulletin.kobe-tokiwa.ac.jp/_src/589/018cb49298814088e4967b82b582a882f191bc.pdf | http://bulletin.kobe-tokiwa.ac.jp/_src/589/018cb49298814088e4967b82b582a882f191bc.pdf"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12442114","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884781","subitem_source_identifier_type":"ISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸大学放射線科"},{"subitem_text_value":"神戸大学放射線科"},{"subitem_text_value":"神戸大学放射線科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸大学病院輸血部"},{"subitem_text_value":"姫路獨協大学薬学部"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ケツエキ シッカン カンジャ ノ テツカジョウショウ ニ タイスル ヒョウカ ホウホウ ノ ケントウ MRI ニヨル ヒ シンシュウテキ テツリョウ テイリョウ ソクテイ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井本, しおん"},{"creatorName":"イモト, シオン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野, 良治"},{"creatorName":"オオノ, ヨシハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"青山, 信和"},{"creatorName":"アオヤマ, ノブカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤井, 正彦"},{"creatorName":"フジイ, マサヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 正徳"},{"creatorName":"ゴトウ, マサノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉本, 健"},{"creatorName":"スギモト, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西郷, 勝康"},{"creatorName":"サイゴウ, カツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMOTO, Shion","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHNO, Yoshiharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AOYAMA, Nobukazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJII, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GOTO, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUGIMOTO, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAIGO, Katsuyasu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-27"}],"displaytype":"detail","filename":"Bulletin03_01.pdf","filesize":[{"value":"923.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bulletin03_01.pdf","url":"https://kobe-tokiwa.repo.nii.ac.jp/record/452/files/Bulletin03_01.pdf"},"version_id":"8eb80d7b-01b1-4e30-a268-74f065902f5a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"鉄過剰症","subitem_subject_scheme":"Other"},{"subitem_subject":"血液疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"肝鉄量","subitem_subject_scheme":"Other"},{"subitem_subject":"MRI","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"Iron overload","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hematological diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liver iron concentration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MRI","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血液疾患患者の鉄過剰症に対する評価方法の検討:MRI による非侵襲的肝鉄量定量測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血液疾患患者の鉄過剰症に対する評価方法の検討:MRI による非侵襲的肝鉄量定量測定"},{"subitem_title":"Assessment of iron overload in patients with hematological diseases: Non-invasive measurement of liver iron concentration using MRI","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["15"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-27"},"publish_date":"2017-07-27","publish_status":"0","recid":"452","relation_version_is_last":true,"title":["血液疾患患者の鉄過剰症に対する評価方法の検討:MRI による非侵襲的肝鉄量定量測定"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T13:17:15.804295+00:00"}