{"created":"2023-06-20T13:09:50.602653+00:00","id":476,"links":{},"metadata":{"_buckets":{"deposit":"7afe7a3b-cf4a-4921-960b-01faed53274e"},"_deposit":{"created_by":3,"id":"476","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"476"},"status":"published"},"_oai":{"id":"oai:kobe-tokiwa.repo.nii.ac.jp:00000476","sets":["6:19"]},"author_link":["5863","5871","5872","5869","5865","5864","5859","5870","5866","5862","5861","5867","5868","5860"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"58","bibliographicPageStart":"51","bibliographic_titles":[{"bibliographic_title":"神戸常盤大学紀要"},{"bibliographic_title":"Bulletin of Kobe Tokiwa University","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"TPA (12-o-tetradecanoylphorbol 13-acetate) induces monocyte/macrophage differentiation and adhesion in the human leukemic HL-60 cell line, and cyclin D1 and p21^waf1 (cell cycle control genes) are overexpressed in TPA-treated adherent HL-60. It is also known that TPA induces apoptosis of the cell line. In this study, to investigate the relationship between differentiation and/or apoptosis induction and cell cycle control genes, we analyzed the expressions of p21^waf1 and cyclin D1 mRNA in adherent and floating cells separately. Using flow cytometry, there was an increase in the apoptosis of floating cells when TPA treatment was applied. Quantitative analysis using real-time polymerase chain reaction revealed that p21^waf1 and cyclin D1 expression was increased in both the floating and adherent cells. There was an increase in apoptosis of floating cells 3 h post-TPA treatment, and by this time the expression of p21^waf1 had already significantly increased. Adherent cells were observed 12 h after TPA treatment, and by this time the expression of p21^waf1 had already increased. These observations suggest that the increased expression of p21^waf1 may play a role in the induction of apoptosis by TPA in HL-60 cells.","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"8","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00009208099","subitem_description_type":"Other"}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://bulletin.kobe-tokiwa.ac.jp/_src/641/p0518fbc8cb389p979d8eq.pdf | http://bulletin.kobe-tokiwa.ac.jp/_src/641/p0518fbc8cb389p979d8eq.pdf"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12442114","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884781","subitem_source_identifier_type":"ISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ヒト ハッケツビョウ サイボウ HL-60 ニ オケル p21^waf1 ノ ハツゲン コウシン 12-o-tetradecanoylphorbol 13-acetate ニ ヨル ブンカ オヨビ アポトーシス ユウドウ トノ カンレン"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松元, 英理子"},{"creatorName":"マツモト, エリコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小木, 友実"},{"creatorName":"コギ, トモミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"榧木, 美佳"},{"creatorName":"カヤキ, ミカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 響子"},{"creatorName":"シバタ, キョウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷, 香里"},{"creatorName":"タニ, カオリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前田, 采音"},{"creatorName":"マエダ, アヤネ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坊垣, 美也子"},{"creatorName":"ボウガキ, ミヤコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Eriko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOGI, Tomomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAYAKI, Mika","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIBATA, Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANI, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAEDA, Ayane","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"BOHGAKI, Miyako","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-08"}],"displaytype":"detail","filename":"Bulletin07_06.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bulletin07_06.pdf","url":"https://kobe-tokiwa.repo.nii.ac.jp/record/476/files/Bulletin07_06.pdf"},"version_id":"68a66354-8d2b-4582-a7cf-327968d519f4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"分化","subitem_subject_scheme":"Other"},{"subitem_subject":"p21Waf1","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclin D1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト白血病細胞HL-60におけるp21^waf1の発現亢進:12-o-tetradecanoylphorbol 13-acetateによる分化およびアポトーシス誘導との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト白血病細胞HL-60におけるp21^waf1の発現亢進:12-o-tetradecanoylphorbol 13-acetateによる分化およびアポトーシス誘導との関連"},{"subitem_title":"Overexpression of p21^waf1 in human leukemic HL-60 cells: correlation with differentiation and apoptosis using 12-o-tetradecanoylphorbol 13-acetate treatment","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["19"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-08"},"publish_date":"2017-09-08","publish_status":"0","recid":"476","relation_version_is_last":true,"title":["ヒト白血病細胞HL-60におけるp21^waf1の発現亢進:12-o-tetradecanoylphorbol 13-acetateによる分化およびアポトーシス誘導との関連"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T13:23:24.074172+00:00"}