@article{oai:kobe-tokiwa.repo.nii.ac.jp:00000478, author = {佐野, 太亮 and 布引, 治 and 岩井, 重寿 and 澤田, 浩秀 and 青野, 早姫 and 天間, 友理香 and 能瀬, 衣沙子 and 宮下, 奈都美 and 猪俣, 啓子 and 山下, 弘幸 and 覚道, 健一 and SANO, Daisuke and NUNOBIKI, Osamu and IWAI, Shigetoshi and SAWADA, Hirohide and AONO, Saki and TENMA, Yurika and NOSE, Isako and MIYASHITA, Natsumi and INOMATA, Keiko and YAMASHITA, Hiroyuki and KAKUDO, Kenichi}, issue = {7}, journal = {神戸常盤大学紀要, Bulletin of Kobe Tokiwa University}, month = {Mar}, note = {Introduction: Thyroid fine-needle cytology is the first line clinical method for thyroid nodule to select patients for surgery, because papillary carcinoma has diagnostic characteristics in cytology, such as nuclear enlargement, nuclear grooves and nuclear inclusions. However over-diagnosis of Hashimoto disease is well known fact to occur frequently.Materials and Methods: Morphometric analysis of cytological samples from Hashimoto disease, papillary carcinoma and benign adenomatous nodule were carried out 4 cases each using Papanicolaou stained conventional smear samples.Results: Sizes of clusters were evaluated by counting number of follicular cells in the cluster. It was larger in papillary carcinoma (63.3/cluster) and benign (43.9/cluster) than Hashimoto disease (18.9/cluster) (P=0.006). The nuclear diameter increased in Hashimoto disease and the average of the longest diameter was 6.5μm and the shortest was 5.5μm, which was overlapped with those of papillary carcinoma. The number of nuclear grooves increased from benign (<1%), Hashimoto disease (6%) to papillary carcinoma (16%).Conclusion: There are significant overlap between Hashimoto disease and papillary carcinoma morphologically. For more accurate diagnosis of Hashimoto disease may be achieved only with combined morphological features., 10, KJ00009208379, 原著, Original Article}, pages = {69--74}, title = {甲状腺乳頭癌と橋本病の鑑別について}, year = {2014}, yomi = {サノ, ダイスケ and ヌノビキ, オサム and イワイ, シゲトシ and サワダ, ヒロヒデ and アオノ, サキ and テンマ, ユリカ and ノセ, イサコ and ミヤシタ, ナツミ and イノマタ, ケイコ and ヤマシタ, ヒロユキ and カクドウ, ケンイチ} }