{"created":"2023-06-20T13:09:52.678597+00:00","id":509,"links":{},"metadata":{"_buckets":{"deposit":"a751f098-7e5d-4b4d-a88e-32981c50180f"},"_deposit":{"created_by":3,"id":"509","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"509"},"status":"published"},"_oai":{"id":"oai:kobe-tokiwa.repo.nii.ac.jp:00000509","sets":["6:11"]},"author_link":["5717","5709","5713","5715","5712","5714","5710","5716","5718","5711"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"119","bibliographicPageStart":"113","bibliographic_titles":[{"bibliographic_title":"神戸常盤大学紀要"},{"bibliographic_title":"Bulletin of Kobe Tokiwa University","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"プレセプシンは敗血症マーカーの一つで、単球において貪食により産生されることが知られているが、単球以外からの産生の報告はない。本研究では好中球からのプレセプシン産生の可能性、及びその産生機所を探索するため、好中球を用いたプレセプシン産生実験及び、貪食、プロテアーゼ阻害実験を行った。好中球を大腸菌で刺激することによりプレセプシン産生が認められた。次にアクチン重合阻害薬による貪食阻害を行ったが、プレセプシン濃度の有意な減少は認められなかった。また、セリンプロテアーゼ阻害薬添加によりプレセプシン濃度は有意に減少したが、一方で好中球エラスターゼ阻害剤の添加ではプレセプシン産生に有意な減少は認められなかった。以上からプレセプシンは単球と同様に好中球からも産生されるが、その産生経路は貪食以外のものであることが示唆された。さらに、エラスターゼ以外のセリンプロテアーゼも産生に関与する可能性が推測された。","subitem_description_type":"Other"}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Presepsin, which is produced in monocytes via its phagocytosis, is one of the biomarker proteins for sepsis, but it is unknown whether other cells secrete presepsin besides monocytes. To clarify the mechanism of presepsin production, we studied presepsin production from neutrophils and effects of inhibitors of phagocytosis and serine protease. We confirmed that prsepsin levels increased significantly when neutrophils were stimulated by Escherichia coli (E. coli). In phagocytosis blocking assay, no presepsin changes were observed nevertheless phagocytosis were weakened in the cells treated cytochalasin D for blocking actin polymerization. In addition, presepsin production of the cells treated with serine protease inhibitor were significantly decreased, on the other hand in cells treated neutrophil elastase inhibitor, presepsin production were a little suppressed. These results indicate that neutrophils as well as monocytes produce presepsin but different pathways from the phagocytosis, and furthermore serine proteases other than elastase may be involved in presepsin production.","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"15","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00010205259","subitem_description_type":"Other"}]},"item_3_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"報告","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Report","subitem_description_type":"Other"}]},"item_3_identifier_14":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://bulletin.kobe-tokiwa.ac.jp/_src/687/1595f18d90208da89z97s8eu.pdf | http://bulletin.kobe-tokiwa.ac.jp/_src/687/1595f18d90208da89z97s8eu.pdf"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12442114","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884781","subitem_source_identifier_type":"ISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科"},{"subitem_text_value":"神戸常盤大学保健科学部医療検査学科・教育イノベーション機構"}]},"item_3_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"コウチュウキュウ ニ オケル プレセプシン ノ サンセイ メカニズム ニ カンスル ケントウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"溝越, 祐志"},{"creatorName":"ミゾコシ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 健吾"},{"creatorName":"カトウ, ケンゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤村, 暢"},{"creatorName":"サワムラ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澁谷, 雪子"},{"creatorName":"シブヤ, ユキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野村, 秀明"},{"creatorName":"ノムラ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIZOKOSHI, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATO, Kengo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAWAMURA, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIBUYA, Yukiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NOMURA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-08"}],"displaytype":"detail","filename":"Bulletin09_13.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bulletin09_13.pdf","url":"https://kobe-tokiwa.repo.nii.ac.jp/record/509/files/Bulletin09_13.pdf"},"version_id":"b66d3230-1229-4e83-9ad9-753699947619"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"プレセプシン","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球","subitem_subject_scheme":"Other"},{"subitem_subject":"貧食","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球エラスターゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"presepsin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phagocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil elastase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"好中球におけるプレセプシンの産生メカニズムに関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"好中球におけるプレセプシンの産生メカニズムに関する検討"},{"subitem_title":"Neutrophils can produce presepsin in phagocytosis-independent pathways","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-08"},"publish_date":"2017-09-08","publish_status":"0","recid":"509","relation_version_is_last":true,"title":["好中球におけるプレセプシンの産生メカニズムに関する検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T13:24:33.362813+00:00"}