@article{oai:kobe-tokiwa.repo.nii.ac.jp:00000729,
 author = {片山, 俊郎 and 馬場, 茂明 and KATAYAMA, Toshiro and BABA, Shigeaki},
 journal = {神戸常盤短期大学紀要, Bulletin of Kobe Tokiwa College},
 month = {Mar},
 note = {Protein induced by vitamin K absence orantagonist II (PIVKA-II)は肝細胞癌(HCC)の腫瘍マーカーとして有名であり,この診断有用性は確認されている。腫瘍マーカーの血清濃度は腫瘍サイズの増加とともに一般に増加し,病態に応じてHCCのほとんどは血清PIVKA-IIの増加と関係している。資料は,HCCと診断された患者の腫瘍サイズと血清PIVKA-IIの測定値の時系列データである。治療時間間隔すなわち病態安定期における腫瘍の発育と腫瘍マーカーの増加に対し,飽和状態を持つ運動方程式の変動としてのモデルの解析を試みた。指数方程式とロジスティック方程式は,内因性腫瘍の発育とその反応曲線の時間的変動を記述する最も一般的な生長カイネティクスモデルであり,血清PIVKA-IIのデータ或いは腫瘍サイズのデータの時系列的プロットに指数方程式の時系列変動とロジスティック方程式の時系列変動をプロットし,その適合度を判定した。結果は,肝細胞癌の増殖システムの仮定のもとで記述されたモデルが定性的に成り立つ時間範囲において,モデルの有用性が示唆された。, Protein induced by vitamin K absence or antagonist II (PIVKA-II) is well known as tumor marker of hepatocelluar carcinoma (HCC), and its diagnostic usefulness has been confirmed. Serum levels of tumor markers generally increase along with the increase of tumor size, and most HCCs at some stages are associated with the increase of PIVKA-II in the serum. A document is time series data of measured value of tumor size and serum PIVKA-II level of the patient that HCC was found. The various attempted to model tumor growth and tumor marker increase during the treatment time interval as well as during its unperturbed state have been variations of density-limited kinetic equations. The exponential and logistic equations were popular models currently being employed to describe growth kinetics giving the time behavior of intrinsic tumor growth and its dose-response curve. All that had to be done was the plotting of the fitted exponential or logistic on the plot containing the time and serum PIVKA-II level data or tumor size data. The results emphasized the remarkable predictive ability of the model during an extended period of time in which the modest assumptions of the models were at least approximately true., 10, KJ00000097930},
 pages = {69--74},
 title = {肝細胞癌における腫瘍径とPIVKA-IIの解析学的検討},
 volume = {24},
 year = {2003},
 yomi = {カタヤマ, トシロウ and ババ, シゲアキ}
}