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ヒト絨毛性ゴナドトロピンの臨床的意義と測定における問題点
https://kobe-tokiwa.repo.nii.ac.jp/records/453
https://kobe-tokiwa.repo.nii.ac.jp/records/453866ff01e-4f6e-4ca0-ab2b-b8996baada41
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Bulletin03_02.pdf (1.9 MB)
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| Item type | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-27 | |||||
| タイトル | ||||||
| タイトル | ヒト絨毛性ゴナドトロピンの臨床的意義と測定における問題点 | |||||
| タイトル | ||||||
| タイトル | Clinical Significance of hCG and Problems in Measuring hCG Levels using Recent Immunological Detection Assays | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | regular-hCG | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hyperglycosylated hCG | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hCG関連ペプチド | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | モノクローナル抗体 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 腫瘍マーカー | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12442114 | |||||
| 論文名よみ | ||||||
| タイトル | ヒト ジュウモウセイ ゴナドロビン ノ リンショウテキ イギ ト ソクテイ ニ オケル モンダイテン | |||||
| 著者 |
澁谷, 雪子
× 澁谷, 雪子× 高松, 邦彦× 足高, 善彦× SHIBUYA, Yukiko× TAKAMATSU, Kunihiko× ASHITAKA, Yoshihiko |
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| 著者所属(日) | ||||||
| 値 | 神戸常盤大学保健科学部医療検査学科 | |||||
| 著者所属(日) | ||||||
| 値 | 神戸常盤大学短期大学部口腔保健学科 | |||||
| 著者所属(日) | ||||||
| 値 | 神戸常盤大学保健科学部医療検査学科 | |||||
| 記事種別(日) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 総説 | |||||
| 記事種別(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Review | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Human chorionic gonadotropin is a glycoprotein hormone composed of α and β subunits, and shows a seat-belt structure three-dimensionally. The α subunit is identical to those of pituitary glycoprotein hormones, FSH, LH, and TSH. The biochemical characteristics of hCG, the amino acid sequences,carbohydrate structures, and biosynthetic pathways, were clarified in the 1970's. Recent genomic studies demonstrated that hCG is coded by multiple copies of genes that form a cluster at 19q13.33 on chromosome 19. A novel hCG molecule with a different immunoreactivity has been identified. It has the same amino acid sequences as regular hCG (R-hCG), but has a higher carbohydrate content than regular hCG, and has therefore been named hyperglycosylated hCG (H-hCG). Although R-hCG is secreted by the syncytiotrophoblast, H-hCG is produced in the cytotrophoblast, and promotes the invasion of the fertilized ovum into the endometrium during the first two weeks of gestation. H-hCG is also secreted in choriocarcinoma and is related to malignancies. By the 1980's, hCG was being measured immunologically using polyclonal antibodies. Sandwichimmunoassays with monoclonal antibodies and improved detection systems have now replaced the old immunoassay systems. The new systems have enabled the detection and discrimination of not only R-hCG and H-hCG but also various previously identified hCG-related peptides that result from degradation. However, false negative and false positive results, which are caused by increased levels of the hCG-related peptides and heterophilic antibodies, respectively, have been reported in some cases. To increase the accuracy of these analyses, specific protocols using both serum and urine as test samples should be applied to the measurement hCG levels, especially for diagnosis and treatment of choriocarcinoma. | |||||
| 書誌情報 |
神戸常盤大学紀要 en : Bulletin of Kobe Tokiwa University 号 3, p. 11-27, 発行日 2011-04-01 |
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| URL | ||||||
| 識別子 | http://bulletin.kobe-tokiwa.ac.jp/_src/590/02918d90e08140e0f92j90e18eq91bc2028129.pdf | http://bulletin.kobe-tokiwa.ac.jp/_src/590/02918d90e08140e0f92j90e18eq91bc2028129.pdf | |||||
| 識別子タイプ | URI | |||||
| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00008894019 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 21884781 | |||||
